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Welcome to The Cancer Information Network
 
Adult Brain Tumor Treatment Information
for Physicians

Important: This information is intended mainly for use by doctors and other health care professionals. If you have questions about this topic, you can ask your doctor, or call the Cancer Information Service at 1-800-4-CANCER (1-800-422-6237).


RECURRENT ADULT BRAIN TUMOR

Treatment options:

Standard:

1. Surgery alone or in conjunction with chemotherapy.[1-3]

2. Radiation therapy if not previously used, alone or with chemotherapy.

3. Interstitial irradiation.[4]

Under clinical evaluation:
Numerous clinical trials (particularly phase II trials) are evaluating the
use of newer drugs in the treatment of brain tumors.

Carmustine (BCNU) impregnated polymer may be implanted during surgery.[5,6]

References:
  1. Salcman M, Kaplan RS, Ducker TB, et al.: Effect of age and reoperation on survival in the combined modality treatment of malignant astrocytoma. Neurosurgery 10(4): 454-463, 1982.
  2. Rodriguez L, Levin V: Does chemotherapy benefit the patient with a central nervous system glioma? Oncology (Huntington NY) 1(9): 29-36, 1987.
  3. Young B, Oldfield EH, Markesbery WR, et al.: Reoperation for glioblastoma. Journal of Neurosurgery 55(6): 917-921, 1981.
  4. Leibel SA, Gutin PH, Sneed PK, et al.: Interstitial irradiation for the treatment of primary and metastatic brain tumors. Cancer: Principles and Practice of Oncology Updates 3(7): 1-11, 1989.
  5. Brem H, Piantadosi S, Burger PC, et al.: Placebo-controlled trial of safety and efficacy of intraoperative controlled delivery by biodegradable polymers of chemotherapy for recurrent gliomas. Lancet 345(8956): 1008-1012, 1995.
  6. Brem H, Ewend MG, Piantadosi S, et al.: The safety of interstitial chemotherapy with BCNU-loaded polymer followed by radiation therapy in the treatment of newly diagnosed malignant gliomas: phase I trial. Journal of Neuro-Oncology 26(2): 111-123, 1995.

Date Last Modified: 09/1999

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