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First Steps After Diagnosis of Cancer
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| Welcome
to The Cancer Information Network |
Adult
Brain Tumor Treatment Information
for Physicians
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Important: This
information is intended mainly for use by doctors and other health care
professionals. If you have questions about this topic, you can ask your
doctor, or call the Cancer Information Service at 1-800-4-CANCER
(1-800-422-6237).
RECURRENT ADULT BRAIN TUMOR
Treatment options:
Standard:
- 1. Surgery alone or in conjunction with chemotherapy.[1-3]
2. Radiation therapy if not previously used, alone or with
chemotherapy.
3. Interstitial irradiation.[4]
Under clinical evaluation:
- Numerous clinical trials (particularly phase II trials) are evaluating
the
use of newer drugs in the treatment of brain tumors.
Carmustine (BCNU) impregnated polymer may be implanted during
surgery.[5,6]
References:
- Salcman M, Kaplan RS, Ducker TB, et al.: Effect of age
and reoperation on survival in the combined modality treatment of
malignant astrocytoma. Neurosurgery 10(4): 454-463, 1982.
Rodriguez L, Levin V: Does chemotherapy benefit
the patient with a central nervous system glioma? Oncology (Huntington
NY) 1(9): 29-36, 1987.
Young B, Oldfield EH, Markesbery WR, et al.:
Reoperation for glioblastoma. Journal of Neurosurgery 55(6): 917-921,
1981.
Leibel SA, Gutin PH, Sneed PK, et al.:
Interstitial irradiation for the treatment of primary and metastatic
brain tumors. Cancer: Principles and Practice of Oncology Updates 3(7):
1-11, 1989.
Brem H, Piantadosi S, Burger PC, et al.:
Placebo-controlled trial of safety and efficacy of intraoperative
controlled delivery by biodegradable polymers of chemotherapy for
recurrent gliomas. Lancet 345(8956): 1008-1012, 1995.
Brem H, Ewend MG, Piantadosi S, et al.: The
safety of interstitial chemotherapy with BCNU-loaded polymer followed by
radiation therapy in the treatment of newly diagnosed malignant gliomas:
phase I trial. Journal of Neuro-Oncology 26(2): 111-123, 1995.
Date Last Modified: 09/1999
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